An Update on the pathogenesis of Diabetes Mellitus
نویسنده
چکیده
The term "Diabetes mellitus" encompasses a heterogeneous group of disorders characterized by insulin hyposecretion and/or insensitivity. Type 1 (insulin-dependent) diabetes mellitus is thought to have an autosomal recessive inheritance and an autoimmune pathogenesis, exhibited by lymphocytic insulitis. The latter may be triggered by viruses or chemical agents. Type 2 (non-insulin-dependent) diabetes mellitus has a stronger genetic association. It is associated with obesity. Hyalinization and fibrosis are seen in the pancreatic islets of Langerhans, and the peripheral target cells are deficient in insulin receptors.This paper summarizes current knowledge regarding pathology and pathophysiology of both types of primary diabetes mellitus.
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